Evaluation of eggshell membrane as an alternative biopolymeric matrix for delivery of nimesulide

Introduction: Eggshell membrane (ESM) is a tissue found between the eggshell and albumen of eggs that has attractive properties for use in drug delivery systems. Aim: To incorporate ESM used it as model release studies. The color change FTIR analysis biopolymer proved incorporation nimesulide ESM. Results: uptake was 176.83 122.69 mg g-1 by natural cross-linked Release studies were carried out using spectrophotometric flow system simulated intestinal fluid pH 7.4. profiles showed after 60 minutes 54.55 42.58 % released from ESM, respectively. Kinetics parameters indicated better described Higuchi through non-Fickian release. Conclusion: Considering these results potential to become polymeric matrix